The Metabolic Programming of Pubertal Onset
Clinton Roddick, Mark Harris, Paul L. Hofman2024Clinical EndocrinologyReview
Endocrine (ADH/ACTH/MSH)Hypothalamic-PituitaryNeurologicalReproductive
Abstract
The mechanism for this appears to be mediated through metabolic signals, such as leptin and insulin, on the kisspeptin-neuronal nitric oxide-gonadotropin releasing hormone (KiNG) axis. Exposed children have an elevated risk of childhood obesity and display a phenotype of hyperinsunlinaemia and hyperleptinaemia. These metabolic changes permit an earlier attainment of the nutritional "threshold" for puberty. Unfortunately, this cycle may be amplified across subsequent generations, however early intervention may help "rescue" progression of this programming.
Part of CIRS biomarkers research · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
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