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Cytokine-neurotransmitter interactions in the brain

De Simoni MG, Imeri L1998NeurosignalsReview
CardiovascularEndocrine (ADH/ACTH/MSH)GastrointestinalHypothalamic-PituitaryImmune/InnateMusculoskeletalNeurologicalOcularRespiratory/Sinus

Abstract

The data reviewed in this study show that immune-active molecules, such as infectious agents and their components, and cytokines, may induce profound alterations in several neurotransmitters in the CNS. The activation of the immune system elicits fever, behavioral and neuroendocrine changes and may be involved in neuropathological changes occurring in CNS conditions. These effects may be achieved through and accounted for by the changes induced in central neurotransmitters and in the neuroendocrine system by immune challenges. The present review will summarize the available evidence of the reciprocal interactions between cytokines and neurotransmitters in the CNS.

Part of Endotoxins research, Mold & water-damaged buildings research, Mycotoxins research, CIRS biomarkers research · Curated by Lauren Lowenstein, The Biotoxin Lady

Key Biomarkers

Symptom Clusters

Constitutional: fatigue, night sweats, excessive thirst, appetite swingsGeneral: headache, frequent urinationMusculoskeletal: muscle aches, joint pain, ice pick painNeurological: memory loss, concentration difficulty, confusion, word finding difficulty, light sensitivityNeuropsychiatric: mood swings, sleep disturbanceRespiratory: cough, shortness of breath, sinus congestionSensory: tingling in extremities