Zygomycetes Hyphae Trigger an Early, Robust Proinflammatory Response in Human Polymorphonuclear Neutrophils through Toll-Like Receptor 2 Induction but Display Relative Resistance to Oxidative Damage
Chamilos G, Lewis G, Walsh T +1 more2008Antimicrobial Agents and ChemotherapyJournal Article
Immune/Innate
Abstract
Human polymorphonuclear neutrophils (HPMNs) displayed attenuated hyphal damage associated with impaired O 2 − release following exposure to Rhizopus oryzae versus that with Aspergillus fumigatus . Exposure of HPMNs to R. oryzae hyphae resulted in upregulation in Toll-like receptor 2 mRNA and a robust proinflammatory gene expression with rapid (1-h) induction of NF-κB pathway-related genes.
Part of Mold & water-damaged buildings research · Curated by Lauren Lowenstein, The Biotoxin Lady
Cited By (2)
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