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Matrix metalloproteinases as modulators of inflammation and innate immunity

Parks WC, Wilson CL, López-Boado YS2004Nature reviews. ImmunologyReview
10.1038/nri1418PubMed
CardiovascularEndocrine (ADH/ACTH/MSH)GastrointestinalHypothalamic-PituitaryImmune/InnateMusculoskeletalNeurologicalOcularRespiratory/Sinus
Bacterial EndotoxinsIndoor Mold (Stachybotrys, Aspergillus, etc.)MycotoxinsVolatile Organic Compounds (VOCs)Water-Damaged Buildings (WDB)

Abstract

Key Biomarkers

Alpha Melanocyte Stimulating Hormone (MSH)Immunoglobulin E (IgE)LeptinMatrix Metalloproteinase 9 (MMP9)Vascular Endothelial Growth Factor (VEGF)Visual Contrast Sensitivity (VCS)

Symptom Clusters

Appetite swingsConfusionCoughDifficulty with concentrationExcessive thirstFatigueFrequent urinationHeadacheIce pick painJoint painLight sensitivityMemory lossMood swingsMuscle achesNight sweatsShortness of breathSinus congestionSleep disturbanceTingling in extremitiesWord finding difficulty

Cited By (2)

  • Sick building syndrome (SBS) and exposure to water-damaged buildings: Time series study, clinical trial and mechanismsNeurotoxicology and Teratology · 2006
  • Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in healthArthritis Research & Therapy · 2006

References (2)

  • Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory diseaseNature · 1992
  • Matrix Metalloproteinase-9 Is Required for Adequate Angiogenic Revascularization of Ischemic TissuesCirculation Research · 2004

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