Leptin Modulates Neutrophil Phagocytosis ofKlebsiella pneumoniae
Moore SI, Huffnagle GB, Chen GH +2 more2003Infection and ImmunityJournal Article
Endocrine (ADH/ACTH/MSH)Immune/Innate
Abstract
Leptin is a pleiotropic hormone-cytokine known to regulate energy homeostasis and immune function. Neutrophils from leptin-deficient mice exhibited impaired phagocytosis ofKlebsiella pneumoniaeopsonized with serum containing complement and reduced CD11b expression that could be restored with exogenous leptin. These results suggest that leptin is required for normal neutrophil complement-mediated phagocytosis of bacteria.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
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