Antifungal combinations against Candida albicans biofilm in vitro
Bachmann SP, Ramage G, VandeWalle K +3 more2003Antimicrobial Agents and ChemotherapyJournal Article
Abstract
Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.
References (4)
- Antifungal Susceptibility ofCandidaBiofilms: Unique Efficacy of Amphotericin B Lipid Formulations and EchinocandinsAntimicrobial Agents and Chemotherapy · 2002
- Standardized Method for In Vitro Antifungal Susceptibility Testing of Candida albicans BiofilmsAntimicrobial Agents and Chemotherapy · 2001
- In Vitro Pharmacodynamic Properties of Three Antifungal Agents against PreformedCandida albicansBiofilms Determined by Time-Kill StudiesAntimicrobial Agents and Chemotherapy · 2002
- Riddle of biofilm resistanceAntimicrobial Agents and Chemotherapy · 2001