In Vitro Pharmacodynamic Properties of Three Antifungal Agents against PreformedCandida albicansBiofilms Determined by Time-Kill Studies

Ramage G; VandeWalle K; Bachmann SP; Wickes BL; Lopez-Ribot JL

doi:10.1128/aac.46.11.3634-3636.2002

In Vitro Pharmacodynamic Properties of Three Antifungal Agents against PreformedCandida albicansBiofilms Determined by Time-Kill Studies

Ramage G, VandeWalle K, Bachmann SP +2 more2002Antimicrobial Agents and ChemotherapyJournal Article

10.1128/aac.46.11.3634-3636.2002 PubMed Free full text

Abstract

We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin againstCandida albicansbiofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.

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Cited By (2)

Effects of Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs on Biofilms and Planktonic Cells of Candida albicansAntimicrobial Agents and Chemotherapy · 2004
Antifungal combinations against Candida albicans biofilm in vitroAntimicrobial Agents and Chemotherapy · 2003

References (2)

Antifungal Susceptibility ofCandidaBiofilms: Unique Efficacy of Amphotericin B Lipid Formulations and EchinocandinsAntimicrobial Agents and Chemotherapy · 2002
Standardized Method for In Vitro Antifungal Susceptibility Testing of Candida albicans BiofilmsAntimicrobial Agents and Chemotherapy · 2001