Defensins: antimicrobial peptides of innate immunity
Ganz T2003Nature reviews. ImmunologyReview
DermatologicalGastrointestinalImmune/InnateRespiratory/Sinus
Abstract
The production of natural antibiotic peptides has emerged as an important mechanism of innate immunity in plants and animals. Defensins are diverse members of a large family of antimicrobial peptides, contributing to the antimicrobial action of granulocytes, mucosal host defence in the small intestine and epithelial host defence in the skin and elsewhere. This review, inspired by a spate of recent studies of defensins in human diseases and animal models, focuses on the biological function of defensins.
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- Chemoattraction of Macrophages, T Lymphocytes, and Mast Cells Is Evolutionarily Conserved within the Human α-Defensin FamilyThe Journal of Immunology · 2007
- Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicineThe EPMA Journal · 2021
- Staphylococcus aureus Infection of Epidermal Keratinocytes Promotes Expression of Innate Antimicrobial PeptidesInfection and Immunity · 2005
- Paneth cell a-defensins from rhesus macaque small intestineInfection and Immunity · 2004
- Zwirner J. beta-defensins chemoattract macrophages and mast cells but not lymphocytes and dendritic cells: CCR6 is not involved
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