Detection of gliotoxin in experimental and human aspergillosis
Lewis RE, Wiederhold NP, Chi J +3 more2005Infection and ImmunityJournal Article
Immune/InnateRespiratory/Sinus
Indoor Mold (Stachybotrys, Aspergillus, etc.)Mycotoxins
Abstract
ABSTRACT Gliotoxin was measured in the lungs (mean, 3,976 ± 1,662 ng/g of tissue) and sera (mean, 36.5 ± 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.
Key Biomarkers
Gliotoxin
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- Fungal Toxins and Host Immune ResponsesFrontiers in Microbiology · 2021
- Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytesBlood · 2005
- Intranasal Aspergillus fumigatus exposure induces eosinophilic inflammation and olfactory sensory neuron cell death in miceOtolaryngology · 2008
- Effectsof Aspergillus fumigatusgliotoxin and methylprednisolone on human neutrophils: implications for the pathogenesis of invasive aspergillosisJournal of Leukocyte Biology · 2007
- Chronic Illness Associated with Mold and Mycotoxins: Is Naso-Sinus Fungal Biofilm the Culprit?Toxins · 2014
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