HLA-DQw3 in Japanese Summer-type Hypersensitivity Pneumonitis Induced by Trichosporon cutaneum
Ando M, Hirayama K, Soda K +3 more1989American Review of Respiratory DiseaseJournal Article
Immune/InnateRespiratory/Sinus
Indoor Mold (Stachybotrys, Aspergillus, etc.)
Abstract
The phenotype of the major histocompatibility complex, loci A, B, C, DR, and DQ, was studied in 66 patients with Japanese summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum, and the results were compared with those obtained from 472 normal healthy subjects. Our results showed an increase in the frequency of HLA-DQw3 antigen in the patients (66% compared with 49% in the normal healthy control subjects: chi 2 = 5.48, p = 0.018, RR = 1.92), suggesting the importance of the host factors for the generation of this disease. The association between HLA-DQw3 as an immune suppression gene and the disease is discussed.
Key Biomarkers
HLA-DQw3
Symptom Clusters
Hypersensitivity pneumonitis
Cited By (3)
- Diagnosis and Evaluation of Hypersensitivity PneumonitisCHEST Journal · 2021
- Immunogenetic basis of environmental lung disease: lessons from the berylliosis modelEuropean Respiratory Journal · 1998
- Diagnosis and Treatment of Hypersensitivity Pneumonitis: S2k Guideline of the German Respiratory Society and the German Society for Allergology and Clinical ImmunologyRespiration · 2025
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