Stachylysin May Be a Cause of Hemorrhaging in Humans Exposed to Stachybotrys chartarum
Abstract
ABSTRACT Stachybotrys chartarum is a toxigenic fungus that has been associated with human health concerns such as nasal bleeding in adults and pulmonary hemosiderosis (PH) in infants. Seven of eight strains of S. chartarum isolated from homes of infants with PH in Cleveland, Ohio, and the strain from the lung of an infant with PH in Texas produced stachylysin in tryptic soy broth (TSB), whereas only one out of eight strains isolated from control homes produced stachylysin. However, all strains produced stachylysin when grown on TSB with 0.7% sheep's blood. When stachylysin was injected into Lumbricus terrestis , the erythrocruorin hemoglobin (absorbance peaks at 280 and 415 nm) was released, resulting in a lethal effect. These results support the hypothesis that stachylysin may be one agent responsible for hemorrhaging in humans.
Key Biomarkers
Symptom Clusters
Cited By (7)
- Intranasal exposure to a damp building mould, Stachybotrys chartarum, induces lung inflammation in mice by satratoxin‐independent mechanismsClinical & Experimental Allergy · 2003
- Emission exposure model for the transport of toxic moldIndoor and Built Environment · 2004
- Stachybotrys chartarum, Trichothecene Mycotoxins, and Damp Building–Related Illness: New Insights into a Public Health EnigmaToxicological Sciences · 2008
- Mycotoxin production by indoor moldsFungal Genetics and Biology · 2003
- Acute Inflammatory Responses to Stachybotrys chartarum in the Lungs of Infant Rats: Time Course and Possible MechanismsToxicological Sciences · 2005
- Testing the Toxicity of Stachybotrys chartarum in Indoor Environments—A Case StudyEnergies · 2021
- Possible role of fungal hemolysins in sick building syndromeAdvances in applied microbiology · 2004
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