Effects of chronic sepsis on the voltage-gated sodium channel in isolated rat muscle fibers
Benoît Rossignol, Gildas Guéret, Jean‐Pierre Pennec +4 more2007Critical Care MedicineJournal Article
Immune/InnateMusculoskeletal
Abstract
Chronic inflammation and sepsis induced modifications of sodium channel properties that could contribute to muscular inexcitability. This inexcitability can be elicited by a modification of properties or type of voltage-gated sodium channels. Our results lead us to explain this inexcitability by an up-regulation of NaV 1.5 sodium channel.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
NaV 1.5 sodium channel
Symptom Clusters
muscular inexcitability
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