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Anaphylatoxins

Haas PJ, van Strijp J2007Immunologic ResearchReview
10.1007/BF02697367PubMed
Immune/InnateRespiratory/Sinus

Abstract

Activation of the complement system plays a crucial role in the pathogenesis of infection and inflammation. Especially the complement activation products C3a and C5a, known as the anaphylatoxins, are potent proinflammatory mediators. In addition to their evident role in innate immunity, it is clear that the anaphylatoxins also play a role in regulation of adaptive immune responses. The anaphylatoxins play a role in a variety of infectious and inflammatory diseases like sepsis, ischemia-reperfusion injury, immune complex diseases, and hypersensitivity diseases like asthma. In this review we discuss the role of anaphylatoxins in infection and inflammation. Furthermore, we focus on bacterial complement evasion strategies that can provide tools for further research on pathogenesis of infectious diseases and a better understanding of the role of complement and anaphylatoxins in infection and inflammation.

Key Biomarkers

AnaphylatoxinsC3aC5aComplement Activation Products

Symptom Clusters

AsthmaImmune complex diseasesIschemia-reperfusion injurySepsis

Cited By (1)

  • The complement cascade in lung injury and diseaseRespiratory Research · 2024

References (9)

  • Anaphylatoxins and infectious and non-infectious inflammatory diseasesMolecular Immunology · 2001
  • The proinflammatory mediators C3a and C5a are essential for liver regenerationThe Journal of Experimental Medicine · 2003
  • Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammationThe FASEB Journal · 2003
  • A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthmaJournal of Clinical Investigation · 2006
  • Comparative study on biological activities of various anaphylatoxins (C4a, C3a, C5a)Inflammation · 1981
  • Cutting Edge: Human Anaphylatoxin C4a Is a Potent Agonist of the Guinea Pig But Not the Human C3a Receptor,

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