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The complement cascade in lung injury and disease

Maria G. Detsika, Kostas Palamaris, Ioanna Dimopoulou +1 more2024Respiratory ResearchJournal Article
10.1186/s12931-023-02657-2PubMedFree full text
Immune/InnateRespiratory/Sinus

Abstract

The complement system contributes to the progression of the acute and chronic lung diseases. Better understanding of the underlying mechanisms will provide groundwork to develop new strategy to target complement factors for treatment of lung diseases.

References (4)

  • AnaphylatoxinsImmunologic Research · 2007
  • Expression of the Complement Anaphylatoxin C3a and C5a Receptors on Bronchial Epithelial and Smooth Muscle Cells in Models of Sepsis and AsthmaThe Journal of Immunology · 2001
  • A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthmaJournal of Clinical Investigation · 2006
  • Complement factors C3a, C4a, and C5a in chronic obstructive pulmonary disease and asthmaAmerican Journal of Respiratory Cell and Molecular Biology · 2004

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