The T helper 17-regulatory T cell axis in transplant rejection and tolerance
Peter Mitchell, Behdad Afzali, Giovanna Lombardi +1 more2009Current Opinion in Organ TransplantationReview
Abstract
The plasticity of the Treg population during inflammation presents a challenge to the use of Tregs as a therapeutic tool in solid organ transplantation. Investigations into the Th17-Treg axis have identified a number of potential pharmacological targets to avoid the risk of conversion to Th17 cells, but further work must be done before we can separate the benefits of Treg therapy from the hazards of the Th17 response.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
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