In vitro effects of ciprofloxacin and roxithromycin on apoptosis of jurkat T lymphocytes
Jun YT, Kim HJ, Song MJ +7 more2003Antimicrobial Agents and ChemotherapyJournal Article
Abstract
ABSTRACTCiprofloxacin (CPFX) and roxithromycin (RXM) induced apoptosis of activated Jurkat T cells in vitro. CPFX showed concentration-dependent acceleration of apoptosis of activated Jurkat T cells by enhancing the expression of FasL and activities of caspase-3 and -8. RXM accelerated cell death, enhanced expression of FasL and caspase-3 but not caspase-8, and did not show the concentration dependency.