Combined Toxicity of the Most Common Indoor Aspergilli
Abstract
The most common Aspergilli isolated from indoor air samples from occupied buildings and a grain mill were extracted and analyzed for their combined (Flavi + Nigri, Versicolores + Nigri) cytotoxic, genotoxic and pro-inflammatory properties on human adenocarcinoma cells (A549) and monocytic leukemia cells induced in macrophages (THP-1 macrophages). Metabolite mixtures from the Aspergilli series Nigri increase the cytotoxic and genotoxic potency of Flavi extracts in A549 cells suggesting additive and/or synergistic effects, while antagonizing the cytotoxic potency of Versicolores extracts in THP-1 macrophages and genotoxicity in A549 cells. All tested combinations significantly decreased IL-5 and IL-17, while IL-1β, TNF-α and IL-6 relative concentrations were increased. Exploring the toxicity of extracted Aspergilli deepens the understanding of intersections and interspecies differences in events of chronic exposure to their inhalable mycoparticles.
Key Biomarkers
References (8)
- Fungal Fragments as Indoor Air BiocontaminantsApplied and Environmental Microbiology · 2002
- Co-occurrence of toxic bacterial and fungal secondary metabolites in moisture-damaged indoor environmentsIndoor Air · 2011
- Occurrence of Toxigenic Aspergillus versicolor Isolates and Sterigmatocystin in Carpet Dust from Damp Indoor EnvironmentsApplied and Environmental Microbiology · 2002
- DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxinToxicological Sciences · 2010
- Can we use indoor fungi as bioindicators of indoor air quality? Historical perspectives and open questionsThe Science of The Total Environment · 2010
- Mycotoxin production by indoor moldsFungal Genetics and Biology · 2003
- Mycotoxins in crude building materials from water-damaged buildings
Related Papers
- A Transcriptomic Fingerprint for Parkinson's Disease Found in Patients with Chronic Inflammatory Response Syndrome: Implications for Diagnosis, Treatment and PreventionMedical Research Archives · 2024 · 3 shared tags
- Revolutionizing Cancer Treatment: Recent Advances in ImmunotherapyBiomedicines · 2024 · 3 shared tags
- Non-Aspergillus Hyaline Molds: A Host-Based Perspective of Emerging Pathogenic Fungi Causing Sinopulmonary DiseasesJournal of Fungi · 2023 · 3 shared tags
- Infant animal model of pulmonary mycotoxicosis induced by Stachybotrys chartarumMycopathologia · 2002 · 3 shared tags
- The time course of responses to intratracheally instilled toxic Stachybotrys chartarum spores in ratsMycopathologia · 2000 · 3 shared tags
- Babesiosis in asplenic hostsTransactions of the Royal Society of Tropical Medicine and Hygiene · 1984 · 3 shared tags