Pre-pregnancy treatment of semaglutide improves high-fat-diet-induced placental and fetal hypothalamic alterations in a sex-specific manner in rats
Jingyue Wang, Ning Wang, Haonan Guo +7 more2025Biology of ReproductionJournal Article
Endocrine (ADH/ACTH/MSH)Hypothalamic-Pituitary
Abstract
PpSI improves maternal lipid metabolism before and during pregnancy, and improves placental nutritional transport and fetal hypothalamic appetite-related gene expression, which provides a potential strategy for pre-pregnancy intervention in obese women.
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