Accelerated Adaptation of SARS-CoV-2 Variants in Mice Lacking IFITM3 Preserves Distinct Tropism and Pathogenesis
Parker Denz, Jonathan L. Papa, Matthew I. McFadden +4 more2025bioRxiv (Cold Spring Harbor Laboratory)Preprint
Immune/InnateRespiratory/Sinus
Abstract
IFITM3 is a critical barrier to SARS-CoV-2 adaptation in new host speciesMouse-adapted SARS-CoV-2 strains enable comparative pathologyOmicron favors nose and large airways, leading to mild lung pathologyBeta exhibits broad lung replication, driving severe inflammation and dysfunction.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
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