Accelerated Adaptation of SARS-CoV-2 Variants in Mice Lacking IFITM3 Preserves Distinct Tropism and Pathogenesis
Parker Denz, Jonathan L. Papa, Matthew I. McFadden +4 more2025bioRxiv (Cold Spring Harbor Laboratory)Preprint
Immune/InnateRespiratory/Sinus
Abstract
IFITM3 is a critical barrier to SARS-CoV-2 adaptation in new host speciesMouse-adapted SARS-CoV-2 strains enable comparative pathologyOmicron favors nose and large airways, leading to mild lung pathologyBeta exhibits broad lung replication, driving severe inflammation and dysfunction.
Related Papers
- Herbal Therapeutics for CIRS Biomarkers in Autism Spectrum Disorders: A Mechanistic and Molecular Approach for Neuroimmune Pathology in PediatricsMedical Research Archives · 2025 · 2 shared tags
- A Transcriptomic Fingerprint for Parkinson's Disease Found in Patients with Chronic Inflammatory Response Syndrome: Implications for Diagnosis, Treatment and PreventionMedical Research Archives · 2024 · 2 shared tags
- Mold inhalation causes innate immune activation, neural, cognitive and emotional dysfunctionBrain Behavior and Immunity · 2020 · 2 shared tags
- The Interplay Between Obesity and Venous Thromboembolism: From Molecular Aspects to Clinical IssueInternational Journal of Molecular Sciences · 2025 · 2 shared tags
- The Furin-S2′ Site in Avian Coronavirus Plays a Key Role in Central Nervous System Damage ProgressionJournal of Virology · 2021 · 2 shared tags
- THIRTY YEARS OF PUBLISHED RESEARCH ON HUMAN HEALTH EFFECTS OF EXPOSURE TO THE INTERIOR ENVIRONMENT OF WATER-DAMAGED BUILT ENVIRONMENTS