Serum leptin level in rheumatoid arthritis and its relationship with disease activity

Abstract

To evaluate serum leptin levels in rheumatoid arthritis (RA) patients and to investigate its correlation with parameters of disease activity including DAS-28, C- reactive protein (CRP) and ESR. Materials and Methods: This study included 60 rheumatoid arthritis patients attended Ibn-Sina and Al-Salam Teaching Hospitals during the period from December 2013 to June 2014. The study also included 30 apparently healthy individuals as a control group who were age, gender, and merely body mass index matched to rheumatoid arthritis patients. Full clinical assessment of the patients was conducted by consultant rheumatologists/physicians. A Questionnaire Form was completed and DAS-28 was calculated. Five milliliters of blood were collected from patients and controls, then centrifuged and the serum was separated and frozen as aliquots at -20 co until use. The sera were tested by enzyme linked immune-sorbent assay ( ELISA) for leptin. Results: Serum leptin levels in RA patients in comparison to the control group were within normal range. Its value varied ranging between 0.7 to 7.5 ng/ml (in patients), and mean ± stander deviation in RA patients 2.1 ± 4.2 and in controls 3.13 ± 2.30. In RA patients, there was no correlations between serum leptin levels and DAS-28, CRP, ESR. Serum leptin levels positively correlated with body mass index (BMI) in both patient and control groups. Conclusions: Circulating leptin level does not seem to reflect disease activity in rheumatoid arthritis since there is no correlation between its serum levels and parameters of disease activity namely DAS -28, CRP, ESR.

Part of CIRS biomarkers research · Curated by Lauren Lowenstein, The Biotoxin Lady

Key Biomarkers