“Corneal Nerves, CD11c+ Dendritic Cells and Their Impact on Ocular Immune Privilege”
Jérry Y. Niederkorn2021Frontiers in ImmunologyReview
Immune/InnateNeurologicalOcular
Abstract
The eye and the brain have limited capacities for regeneration and as such, immune-mediated inflammation can produce devastating consequences in the form of neurodegenerative diseases of the central nervous system or blindness as a result of ocular inflammatory diseases such as uveitis. Accordingly, both the eye and the brain are designed to limit immune responses and inflammation - a condition known as "immune privilege". Immune privilege is sustained by physiological, anatomical, and regulatory processes that conspire to restrict both adaptive and innate immune responses.
References (4)
- Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humorCurrent Eye Research · 1992
- Ocular immunosuppressive microenvironmentChemical immunology and allergy · 2007
- Special regulatory T cell review: the resurgence of the concept of contrasuppression in immunoregulationImmunology · 2008
- Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humorThe Journal of Immunology · 1994
Related Papers
- In silico design of a TLR4-mediating multiepitope chimeric vaccine against amyotrophic lateral sclerosis via advanced immunoinformaticsJournal of Leukocyte Biology · 2022 · 3 shared tags
- Treatable metabolic and inflammatory abnormalities in Post COVID Syndrome (PCS) define the transcriptomic basis for persistent symptoms: Lessons from CIRSMedical Research Archives · 2021 · 3 shared tags
- Breach and restoration of retinal immune privilege: barrier failure, innate dysregulation, and adaptive autoimmunityFrontiers in Immunology · 2025 · 3 shared tags
- The role of melanocytes in the human choroidal microenvironment and inflammation: Insights from the transcriptomePigment Cell & Melanoma Research · 2021 · 3 shared tags
- Introduction to Chronic Inflammatory Response Syndrome (CIRS)2023 · 3 shared tags
- Case Report: Low pressure hyperbaric oxygen therapy as a potential alternative treatment for chronic inflammatory response syndrome: a case study with notable improvements in fatigue, cognition, and testing