The Therapeutic Effect of Vasoactive Intestinal Peptide on Experimental Arthritis is Associated with CD4+CD25+ T Regulatory Cells
Abstract
Vasoactive intestinal peptide (VIP) has been found to act as a potent anti‐inflammatory factor through regulating the production of both anti‐ and pro‐inflammatory mediators and promoting Th2‐type responses. In this study, we used Chicken collagen II‐induced experimental arthritis (CIA) model in Wistar rats to investigate the potential effects of VIP on rheumatoid arthritis. Our results showed that in vivo treatment of CIA‐induced rats with VIP had great protective benefit at both clinical and histological levels. Disease suppression was associated with the inhibition of T cells proliferation, shifting of the immune response toward a Th2‐type response and expanded CD4+CD25+ Treg in the periphery, which inhibited autoreactive T cell activation/expansion. In conclusion, the study provides evidence that VIP had great protective effect on CIA through its inhibition actions on pathogenic T cells.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
Cited By (2)
- Electro-acupuncture inhibits inflammation reaction by up-regulating vasoactive intestinal peptide in rats with adjuvant-induced arthritisEvidence-based Complementary and Alternative Medicine · 2011
- Identification of the early VIP-regulated transcriptome and its associated, interactome in resting and activated murine CD4 T cellsMolecular Immunology · 2010
References (2)
- CD4+CD25+ regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluidArthritis & Rheumatism · 2004
- Vasoactive intestinal peptide induces CD4+,CD25+ T regulatory cells with therapeutic effect in collagen‐induced arthritisArthritis & Rheumatism · 2006
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