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Clues to VIP function from knockout mice

Hamidi S, Szema A, Lyubsky S +5 more2006Annals of the New York Academy of SciencesJournal Article
10.1196/annals.1317.035PubMed
CardiovascularImmune/InnateRespiratory/Sinus
Bacterial Endotoxins

Abstract

Abstract: We have taken advantage of the availability of vasoactive intestinal polypeptide (VIP) knockout (KO) mice to examine the possible influence of deletion of the VIP gene on: (a) airway reactivity and airway inflammation, as indicators of bronchial asthma; (b) mortality from endotoxemia, a model of septic shock; and (c) the pulmonary circulation. VIP KO mice showed: (a) airway hyperresponsiveness to the cholinergic agonist methacholine, as well as peribronchial and perivascular inflammation; (b) a greater susceptibility to death from endotoxemia; and (c) evidence suggestive of pulmonary hypertension.

Key Biomarkers

Airway hyperresponsivenessPeribronchial inflammationPerivascular inflammationVIP (Vasoactive Intestinal Peptide)

Symptom Clusters

Airway hyperresponsivenessBronchial asthmaPulmonary hypertensionSeptic shock susceptibility

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  • Pulmonary peptidergic innervation remodeling and development of airway hyperresponsiveness induced by RSV persistent infectionPeptides · 2008

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