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VE-Cadherin

Vestweber D2008Arteriosclerosis Thrombosis and Vascular BiologyReview
10.1161/ATVBAHA.107.158014PubMed
Cardiovascular

Abstract

—Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule located at junctions between endothelial cells. In analogy of the role of E-cadherin as major determinant for epithelial cell contact integrity, VE-cadherin is of vital importance for the maintenance and control of endothelial cell contacts. Mechanisms that regulate VE-cadherin–mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis. This review will focus on recent new developments in understanding the role of VE-cadherin in controlling endothelial cell contacts and influencing endothelial cell behavior by various outside-in signaling processes. (Arterioscler Thromb Vasc Biol 2008;28:223-232)

Key Biomarkers

Endothelial cell adhesionLeukocyte extravasationVascular permeabilityVE-cadherin

Cited By (2)

  • Vascular endothelial-cadherin and vascular stabilityCurrent Opinion in Hematology · 2012
  • Sensitivity, specificity of biochemical markers for early prediction of endothelial dysfunction in atherosclerotic obese subjectsAfrican Health Sciences · 2022

References (1)

  • Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesisCell · 1999

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