← Explorer/Network

TGF-beta and CD4+CD25+ Regulatory T cells

Huber S, Schramm C2006Frontiers in bioscienceReview
10.2741/1859PubMedFree full text
Immune/InnateNeurological

Abstract

TGF-beta and CD4+CD25+ regulatory T cells (Treg) both play an important role in the control of immune responses and the maintenance of immune homeostasis. The mechanism of suppression induced by Treg and the factors which regulate Treg function and number, have only begun to be elucidated. TGF-beta seems to act as an effector cytokine involved in the immunosuppressive function of Treg in vitro and in vivo, although its origin and mechanism of action remains to be defined. In addition, TGF-beta signaling in peripheral Treg seems to be essential for the regulation of peripheral Treg numbers and for their immunosuppressive function in vivo. This review will focus on the role of TGF-beta for the generation and expansion of CD4+CD25+ Treg, as well as for their immunosuppressive function in vitro and in vivo.

Key Biomarkers

CD4+CD25+ regulatory cellsTGF-beta

Cited By (1)

  • Chronic psychosocial stress promotes systemic immune activation and the development of inflammatory Th cell responsesBrain Behavior and Immunity · 2010

References (8)

  • Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10The Journal of Immunology · 2004
  • TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and MiceThe Journal of Immunology · 2004
  • Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3The Journal of Experimental Medicine · 2003
  • Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T CellsThe Journal of Immunology · 2004
  • CD4+CD25− T Cells That Express Latency-Associated Peptide on the Surface Suppress CD4+CD45RBhigh-Induced Colitis by a TGF-β-Dependent MechanismThe Journal of Immunology · 2003

Related Papers

  • CGRP sensory neurons promote tissue healing via neutrophils and macrophagesNature · 2024 · 2 shared tags
  • Invited review: Mechanisms of hypophagia during diseaseJournal of Dairy Science · 2021 · 2 shared tags
  • Diabetic complications and prospective immunotherapyFrontiers in Immunology · 2023 · 2 shared tags
  • Gut-Brain Inflammation Due to Toxin-Activated Mast Cells and Microglia in Autism Spectrum DisorderPreprints.org · 2025 · 2 shared tags
  • The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes—New PerspectivesAntioxidants · 2023 · 2 shared tags
  • Herbal Therapeutics for CIRS Biomarkers in Autism Spectrum Disorders: A Mechanistic and Molecular Approach for Neuroimmune Pathology in PediatricsMedical Research Archives · 2025 · 2 shared tags
  • A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral BloodThe Journal of Immunology · 2001
  • Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory CellsThe Journal of Experimental Medicine · 2002
  • Acquisition of anergic and suppressive activities in transforming growth factor- -costimulated CD4+CD25- T cellsInternational Immunology · 2004