Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells
Abstract
Abstract Data regarding the role of TGF-β for the in vivo function of regulatory CD4+CD25+ T cells (Treg) are controversial. A transgenic mouse model with impaired TGF-β signaling specifically in T cells was used to assess the role of endogenous TGF-β for the in vivo function of CD4+CD25+ Treg in a murine model of colitis induced by dextran sulfate. Transfer of wild-type, but not transgenic CD4+CD25+ Treg was found to suppress colitis in wild-type mice. In addition, by transferring CFSE-labeled CD4+CD25+ Treg we could demonstrate that endogenous TGF-β promotes the expansion of CD4+CD25+ Treg in vivo. Transgenic mice themselves developed reduced numbers of peripheral CD4+CD25+ Treg and were more susceptible to the induction of colitis, which could be prevented by the transfer of wild-type Treg. These data indicate that TGF-β signaling in CD4+CD25+ Treg is required for their in vivo expansion and suppressive capacity.
Key Biomarkers
Symptom Clusters
Cited By (14)
- The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune diseaseClinical & Experimental Immunology · 2007
- TGF-β signaling and collagen deposition in chronic rhinosinusitisJournal of Allergy and Clinical Immunology · 2009
- Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune diseaseImmunological Reviews · 2006
- The inflamed central nervous system drives the activation and rapid proliferation of Foxp3+ regulatory T cellsThe Journal of Immunology · 2007
- T regulatory cells and their counterparts: masters of immune regulationClinical & Experimental Allergy · 2009
- Vasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivoJournal of Leukocyte Biology · 2005
- TGF-β1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets
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