Immunomodulatory strategies prevent the development of autoimmune emphysema
Hanaoka M, Nicolls M, Fontenot A +8 more2010Respiratory ResearchJournal Article
Immune/InnateRespiratory/Sinus
Abstract
Background: The presence of anti-endothelial cell antibodies and pathogenic T cells may reflect an autoimmune component in the pathogenesis of emphysema. Whether immune modulatory strategies can protect against the development of emphysema is not known.
Key Biomarkers
active caspase-3anti-endothelial cell antibodiesCD4+CD25+Foxp3+ regulatory T cellsCNTFIL-1αpathogenic T cellsVEGF
Symptom Clusters
alveolar airspace enlargementemphysema
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