CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use
Mottet C, Golshayan D2007Swiss Medical WeeklyReview
Immune/Innate
Abstract
Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.
Key Biomarkers
CD25CD4CTLA4Foxp3TGFB1
References (4)
- CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic ArthritisThe Journal of Immunology · 2004
- CD4+CD25+ T cells inhibit both the induction and effector function of auto-reactive T cells and represent a unique lineage of immunoregulatory cellsThe Journal of Immunology · 1998
- Regulation of immune responses by TGF-betaAnnual Review of Immunology · 1998
- Type 1 T Regulatory Cells and Their Relationship with CD4 + CD25 + T Regulatory CellsNovartis Foundation symposium · 2003
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