Naturally Arising Foxp3-Expressing CD25+CD4+ Regulatory T Cells in Self-Tolerance and Autoimmune Disease

Sakaguchi S, Setoguchi R, Yagi H +1 more2006Current topics in microbiology and immunologyJournal Article

Immune/Innate

Abstract

Naturally arising CD25+CD4+ regulatory T cells, which express the transcription factor Foxp3, play key roles in the maintenance of immunologic self-tolerance and negative control of a variety of physiological and pathological immune responses. The majority of them are produced by the normal thymus as a functionally mature T cell subpopulation specialized for suppressive function. Their generation is in part genetically and developmentally controlled. Genetically determined or environmentally induced abnormality in CD25+CD4+ regulatory T cell development, maintenance, and function can be a cause of autoimmune disease in humans.

Key Biomarkers

CD25CD4CTLA4Foxp3TGFB1

Cited By (5)

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Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunityJournal of Leukocyte Biology · 2010
Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humansNature reviews. Immunology · 2007
Increased Th17 cell frequency concomitant with decreased FoxP3+ Treg cell frequency in the peripheral circulation of patients with carotid artery plaquesInflammation Research · 2012