Long term treatment of chronic Lyme arthritis with benzathine penicillin
Cimmino MA, Accardo S1992Annals of the Rheumatic DiseasesJournal Article
Musculoskeletal
Lyme & Co-Infections
Abstract
The cases are reported of two patients with chronic Lyme arthritis resistant to the recommended antibiotic regimens who were cured by long term treatment with benzathine penicillin. It is suggested that the sustained therapeutic levels of penicillin were effective either by the inhibition of germ replication or by lysis of the spirochaetes when they were leaving their sanctuaries.
References (3)
- Treatment of the early manifestations of Lyme diseaseAnnals of Internal Medicine · 1983
- Successful Parenteral Penicillin Therapy of Established Lyme ArthritisNew England Journal of Medicine · 1985
- Intracellular localization of Borrelia burgdorferi within human endothelial cellsInfection and Immunity · 1991
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