Paraspeckles: nuclear bodies built on long noncoding RNA
Abstract
Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and PSPC1 [paraspeckle protein 1]) are members of the DBHS (Drosophila melanogaster behavior, human splicing) family. These proteins, together with the long nonprotein-coding RNA NEAT1 (MEN-ε/β), associate to form paraspeckles and maintain their integrity. Given the large numbers of long noncoding transcripts currently being discovered through whole transcriptome analysis, paraspeckles may be a paradigm for a class of subnuclear bodies formed around long noncoding RNA.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Cited By (11)
- The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosisMolecular Brain · 2013
- Gene expression profiling of porcine skeletal muscle in the early recovery phase following acute physical activityExperimental Physiology · 2012
- NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodiesMolecular Biology of the Cell · 2014
- Whole-genome screening identifies proteins localized to distinct nuclear bodiesThe Journal of Cell Biology · 2013
- Long non-coding RNAs in nervous system function and diseaseBrain Research · 2010
- Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAsNature Cell Biology · 2011
- Paraspeckle formation during the biogenesis of long non-coding RNAsRNA Biology · 2013
- Nuclear bodies: new insights into assembly/dynamics and disease relevanceCurrent Opinion in Cell Biology · 2014
- Nuclear architecture by RNACurrent Opinion in Genetics & Development · 2012
- Impact of nuclear organization and dynamics on epigenetic regulation in the central nervous system: implications for neurological disease statesAnnals of the New York Academy of Sciences · 2010
- Diverse functions of nuclear non-coding RNAs in eukaryotic gene expressionFrontiers in bioscience · 2012