Role of the melanocortin system in inflammation
Maaser C, Kannengiesser K, Kucharzik T2006Annals of the New York Academy of SciencesReview
Endocrine (ADH/ACTH/MSH)Immune/Innate
Abstract
Abstract: In recent years, scientific interest in melanocortins (MC) has progressively increased due to their wide range of effects and expression on various tissues.Primarily discovered as mediators of skin pigmentation, recent research has shown their important roles in various body functions, such as energy homeostasis, sexual function, and inflammation. The anti‐inflammatory and immunomodulatory properties discovered so far have led to the hypothesis that alpha‐melanocyte‐stimulating hormone (MSH) and its cognate receptors might present potential anti‐inflammatory treatment options.
References (12)
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- Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agentsThe Journal of Immunology · 1998
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