Central administration of alpha-melanocyte-stimulating hormone changes lipid metabolism in chicks

Tachibana T, Oikawa D, Adachi N +2 more2007Comparative Biochemistry and Physiology Part A Molecular & Integrative PhysiologyJournal Article

10.1016/j.cbpa.2007.05.023 PubMed

Endocrine (ADH/ACTH/MSH)Hypothalamic-Pituitary

Abstract

Alpha-melanocyte-stimulating hormone (MSH) is well known as an anorexigenic peptide in the brain of mammals. In addition to this, brain alpha-MSH enhances heat production (HP), indicating that the peptide acts as a catabolic factor in the regulation of energy metabolism. The anorexigenic effect of alpha-MSH is also observed in chicks (Gallus gallus), but no information has been available for its effect on HP. The present study was performed to examine whether intracerebroventricular (ICV) injection of alpha-MSH increases HP in chicks. The injection of alpha-MSH (10 and 100 pmol) did not affect oxygen consumption, carbon dioxide production and HP during the 1 h post-injection period. This result was supported by another result that ICV injection of alpha-MSH did not affect locomotion activity in chicks. In contrast, the respiratory quotient was significantly lowered by the ICV injection of MSH. We also found that alpha-MSH significantly increased plasma non-esterified fatty acid concentrations. In summary, brain alpha-MSH appears to exert generally catabolic effects on lipid metabolism in the chick, but does not appear to be involved in the regulation of HP.

Key Biomarkers

Alpha-melanocyte-stimulating hormone (alpha-MSH)Plasma non-esterified fatty acid concentrationsRespiratory quotient

Symptom Clusters

Energy metabolism regulationLipid metabolism changes

Cited By (1)

Intracerebroventricular administration of α-melanocyte-stimulating hormone (α-MSH) enhances thigmotaxis and induces anxiety-like behavior in the goldfish Carassius auratusPeptides · 2021