Correlation of the IgG index and oligoclonal bands in the cerebrospinal fluid of patients with multiple sclerosis

Abstract

247 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008, 152(2):247–249. © J. Mares, R. Herzig, K. Urbanek, V. Sladkova, J. Sklenarova, V. Bekarek, P. Schneiderka, J. Zapletalova, P. Kanovsky CORRELATION OF THE IGG INDEX AND OLIGOCLONAL BANDS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH MULTIPLE SCLEROSIS Jan Maresa*, Roman Herziga, Karel Urbaneka, Vladimira Sladkovaa, Jaroslava Sklenarovab, Vojtech Bekarekb, Petr Schneiderkab, Jana Zapletalovac, Petr Kanovskya a Department of Neurology, University Hospital, Olomouc, Czech Republic b Department of Clinical Biochemistry, University Hospital, Olomouc c Institute of Biophysics, Palacký University, Olomouc e-mail: maresja@seznam.cz Received: July 22, 2008; Accepted (with revision): December 11, 2008 Key words: Oligoclonal bands/Cerebrospinal fl uid/IgG index/Multiple sclerosis Aims: The aim of this study was to assess the correlation between IgG index values and the number of the oligo- clonal IgG bands (OCB) in the cerebrospinal fl uid (CSF) of patients with multiple sclerosis (MS). Material and Methods: The set of 150 patients consisted of 41 males and 109 females (aged 18–68, mean 36.6 ± 10.1 years). The CSF collected by a lumbar puncture was examined evaluating intrathecal synthesis using the IgG index and determining OCB. The number of alkaline OCB in the CSF was assessed using the method of isoelectric focusing. Pearson’s correlation analysis, and homogeneity χ2 test, Mann-Whitney test, paired-sample t-test (parametric) and Wilcoxon signed-ranks test (nonparametric) were used to evaluate the statistical signifi cance of the results. Results: No positive correlation between the IgG index and the number of OCB was found. Mann-Whitney test also failed to demonstrate any signifi cant diff erence of the IgG index values in patients both with the OCB number ≥ 2 and < 2. Conclusion: This study did not confi rm any correlation between the IgG index values and the OCB number in the CSF of MS patients. INTRODUCTION Immunoglo

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