CD4+CD25+FoxP3+PD1— regulatory T cells in acute and stable relapsing‐remitting multiple sclerosis and their modulation by therapy
Abstract
The intracellular expression of the pro- grammed death receptor 1 (PD1) identifies a subset of naive Treg cells with enhanced suppressive ability; anti- gen stimulation results in the surface expression of PD1. Because the role of Treg impairments in multiple sclerosis (MS) is still contradictory, we analyzed naive PD1 and PD1 Treg cells in peripheral blood and cerebrospinal fluid (CSF) of relapsing-remitting multi- ple sclerosis (RR-MS) patients and of healthy control subjects. Results showed that 1) CSF PD1 Treg cells were significantly augmented in MS patients; 2) PD1 Treg cells were significantly increased in the peripheral blood of patients with stable disease (SMS) compared to those with acute (AMS) disease, and in patients responding to glatiramer acetate (COPA) compared to AMS- and COPA-unresponsive patients; and 3) PD1 Treg cells were similar in CSF and peripheral blood of all groups analyzed. PD1 Treg cells were not increased in the peripheral blood of interferon- (IFN) -respon- sive patients, but the suppressive ability of Treg cells was significantly higher in SMS and in COPA- or IFN- responsive compared to AMS- and COPA-unresponsive individuals. The data herein suggest that PD1 Treg cells play a pivotal role in MS and offer a biological explanation for disease relapse and for the mechanism associated with response to COPA and IFN.—Sar- esella, M., Marventano, I., Longhi, R., Lissoni, F., Trabattoni, D., Mendozzi, L., Caputo, D., Clerici, M. CD4CD25FoxP3PD1 regulatory T cells in acute and stable relapsing-remitting multiple sclerosis and their modulation by therapy. FASEB J. 22, 3500–3508 (2008)
Key Biomarkers
Symptom Clusters
References (4)
- Compromised CD4+ CD25high regulatory T‐cell function in patients with relapsing‐remitting multiple sclerosis is correlated with a reduced frequency of FOXP3‐positive cells and reduced FOXP3 expression at the single‐cell levelImmunology · 2008
- CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic ArthritisThe Journal of Immunology · 2004
- Prevalence of Newly Generated Naive Regulatory T Cells (Treg) Is Critical for Treg Suppressive Function and Determines Treg Dysfunction in Multiple SclerosisThe Journal of Immunology · 2007
- Secondary progressive in contrast to relapsing‐remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T‐cell function and FOXP3 expressionJournal of Neuroscience Research · 2006
Related Papers
- CGRP sensory neurons promote tissue healing via neutrophils and macrophagesNature · 2024 · 2 shared tags
- Invited review: Mechanisms of hypophagia during diseaseJournal of Dairy Science · 2021 · 2 shared tags
- Diabetic complications and prospective immunotherapyFrontiers in Immunology · 2023 · 2 shared tags
- Gut-Brain Inflammation Due to Toxin-Activated Mast Cells and Microglia in Autism Spectrum DisorderPreprints.org · 2025 · 2 shared tags
- The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes—New PerspectivesAntioxidants · 2023 · 2 shared tags
- Herbal Therapeutics for CIRS Biomarkers in Autism Spectrum Disorders: A Mechanistic and Molecular Approach for Neuroimmune Pathology in PediatricsMedical Research Archives · 2025 · 2 shared tags