CD4+CD25+FoxP3+PD1— regulatory T cells in acute and stable relapsing‐remitting multiple sclerosis and their modulation by therapy

Abstract

The intracellular expression of the pro- grammed death receptor 1 (PD1) identifies a subset of naive Treg cells with enhanced suppressive ability; anti- gen stimulation results in the surface expression of PD1. Because the role of Treg impairments in multiple sclerosis (MS) is still contradictory, we analyzed naive PD1 and PD1
Treg cells in peripheral blood and cerebrospinal fluid (CSF) of relapsing-remitting multi- ple sclerosis (RR-MS) patients and of healthy control subjects. Results showed that 1) CSF PD1 Treg cells were significantly augmented in MS patients; 2) PD1 Treg cells were significantly increased in the peripheral blood of patients with stable disease (SMS) compared to those with acute (AMS) disease, and in patients responding to glatiramer acetate (COPA) compared to AMS- and COPA-unresponsive patients; and 3) PD1
Treg cells were similar in CSF and peripheral blood of all groups analyzed. PD1 Treg cells were not increased in the peripheral blood of interferon- (IFN) -respon- sive patients, but the suppressive ability of Treg cells was significantly higher in SMS and in COPA- or IFN- responsive compared to AMS- and COPA-unresponsive individuals. The data herein suggest that PD1 Treg cells play a pivotal role in MS and offer a biological explanation for disease relapse and for the mechanism associated with response to COPA and IFN.—Sar- esella, M., Marventano, I., Longhi, R., Lissoni, F., Trabattoni, D., Mendozzi, L., Caputo, D., Clerici, M. CD4
CD25
FoxP3
PD1 regulatory T cells in acute and stable relapsing-remitting multiple sclerosis and their modulation by therapy. FASEB J. 22, 3500–3508 (2008)

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady

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