Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy
Katz-Brull R, Lenkinski RE, Du Pasquier RA +1 more2004NeurologyJournal Article
Neurological
Abstract
MRI, 1H-MR spectroscopy, immunologic, and virologic studies were performed in search of prognostic factors of disease evolution in patients with progressive multifocal leukoencephalopathy (PML). Acute lesions of PML survivors showed twofold higher standard score of the ratio of myoinositol (a glial marker) to creatine compared with lesions in patients whose disease progressed. Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
JC virus-specific cytotoxic T lymphocytesmyo-inositol
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