Detection of the myo‐inositol 4.06‐ppm resonance by selective J rewinding: Application to human prefrontal cortex in vivo

Abstract

A new proton NMR single‐voxel spectral editing strategy for the rapid measurement of myo‐inositol in human brain is proposed. The spectral editing detects the 4.06‐ppm, weakly coupled resonance by means of selective J rewinding. An 84.6‐ms‐long quadruple‐resonance selective 180° radiofrequency pulse, implemented within an adiabatic‐refocused localization sequence, induces an in‐phase triplet at 4.06 ppm, while eliminating the contribution from creatine, phosphorylethanolamine, lactate, and serine in this spectral region. The myo‐inositol concentration in human prefrontal cortex is estimated to be 5.7 ± 0.9 μmol/g (mean ± SD, n = 7), with reference to NAA at 10 μmol/g. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady