The biological role of dectin-1 in immune response
Abstract
The identification of antigen-recognizing receptors in the innate immune system significantly helped us to understand the initiation and regulation of the innate immune response. Dectin-1 was recently identified as the most important receptor for beta-glucan. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. In this paper, we will mainly focus on the characteristics of dectin-1 and its biological role in immune response.
References (4)
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- The role of the β-glucan receptor Dectin-1 in control of fungal infectionJournal of Leukocyte Biology · 2007
- Macrophage Internalization of Fungal β-Glucans Is Not Necessary for Initiation of Related Inflammatory ResponsesInfection and Immunity · 2005
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