Evolution of the lectin-complement pathway and its role in innate immunity
Abstract
Discrimination between self and non-self by lectins (carbohydrate-binding proteins) is a strategy of innate immunity that is found in both vertebrates and invertebrates. In vertebrates, immune recognition mediated by ficolins (lectins that consist of a fibrinogen-like and a collagen-like domain), as well as by mannose-binding lectins, triggers the activation of the complement system, which results in the activation of novel serine proteases. The presence of a similar lectin-based complement system in ascidians, our closest invertebrate relatives, indicates that the complement system probably had a pivotal role in innate immunity before the evolution of an adaptive immune system in jawed vertebrates.
Key Biomarkers
Cited By (7)
- Collectins and Ficolins: Humoral Lectins of the Innate Immune DefenseAnnual Review of Immunology · 2003
- Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clotImmunology · 2010
- Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathwayThe Journal of Immunology · 2006
- Lectin complement system and pattern recognitionImmunobiology · 2006
- Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathwayAdvances in experimental medicine and biology · 2007
- Ficolins: structure, function and associated diseasesAdvances in experimental medicine and biology · 2008
- The role of complement, C5a and its receptors in sepsis and multiorgan dysfunction syndromeJournal of Investigative Surgery · 2006
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