Chlamydia pneumoniaeEnhances Cytokine-Stimulated Human Monocyte Matrix Metalloproteinases through a Prostaglandin E2-Dependent Mechanism
Kim MP, Gaydos CA, Wood BJ +3 more2005Infection and ImmunityJournal Article
Abstract
Exposure of human monocytes toChlamydia pneumoniaeresulted in a significant enhancement of matrix metalloproteinase (MMP) 1 and 9 production following stimulation with tumor necrosis factor alpha and granulocyte monocyte-colony stimulating factor. The effect ofC. pneumoniaeon monocyte MMPs was mediated through the induction of prostaglandin E2. These findings may have implications for atherosclerotic plaque rupture.
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