MicroRNAs: the fine-tuners of Toll-like receptor signalling

O’Neill L, Sheedy F, McCoy C2011Nature reviews. ImmunologyReview

Immune/Innate

Abstract

Toll-like receptor (TLR) signalling must be tightly regulated to avoid excessive inflammation and to allow for tissue repair and the return to homeostasis after infection and tissue injury. MicroRNAs (miRNAs) have emerged as important controllers of TLR signalling. Several miRNAs are induced by TLR activation in innate immune cells and these and other miRNAs target the 3' untranslated regions of mRNAs encoding components of the TLR signalling system. miRNAs are also proving to be an important link between the innate and adaptive immune systems, and their dysregulation might have a role in the pathogenesis of inflammatory diseases.

Key Biomarkers

microRNAToll-like receptor signaling

Cited By (2)

MicroRNA in TLR signaling and endotoxin toleranceCellular and Molecular Immunology · 2011
Molecular mechanisms underlying the regulation and functional plasticity of FOXP3(+) regulatory T cellsGenes and Immunity · 2012

References (1)

Toll-like receptors in the pathogenesis of human diseaseNature Immunology · 2004