The initiating proteases of the complement system: controlling the cleavage
Duncan RC, Wijeyewickrema LC, Pike RN2008BiochimieReview
Immune/Innate
Abstract
The complement system is a vital component of the host immune system, but when dysregulated, can also cause disease. The system is activated by three pathways: classical, lectin and alternative. The initiating proteases of the classical and lectin pathways have similar domain structure and employ similar mechanisms of activation. The C1r, C1s and MASP-2 proteases have the most defined roles in the activation of the system. This review focuses on the mechanisms whereby their interaction with substrates and inhibitors is regulated.
Key Biomarkers
C1rC1sC4aMASP-2
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