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Eradication of resident bacteria of normal human skin by antimicrobial ointment

Hendley JO, Ashe KM2003Antimicrobial Agents and ChemotherapyJournal Article
Dermatological

Abstract

The application of a topical triple-antibiotic ointment (containing neomycin, polymyxin, and bacitracin) eradicated resident bacteria through 25 layers of the stratum corneum and prevented repopulation of bacteria overnight but not at 1 week. Through 15 layers, mupirocin had some effect, whereas a double-antibiotic ointment had none. The reservoir of resident bacteria in the sebaceous glands is not affected by a topical antibiotic.

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