Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection
Coyle PK, Schutzer SE, Deng Z +4 more2008PLoS ONEJournal Article
CardiovascularImmune/InnateMusculoskeletalNeurological
Lyme & Co-Infections
Abstract
The persistence of symptoms in Lyme disease patients following antibiotic therapy, and their causes, continue to be a matter of intense controversy. The studies presented here explore antibiotic efficacy using nonhuman primates. Rhesus macaques were infected with B. burgdorferi and a portion received aggressive antibiotic therapy 4–6 months later. Multiple
Key Biomarkers
B. burgdorferi antigenB. burgdorferi DNAB. burgdorferi RNABorrelia burgdorferi persistenceC6 diagnostic peptide antibodiesSpirochete detection
Symptom Clusters
Chronic Lyme arthritisChronic relapsing infectionNeuroborreliosisPersistent symptoms despite antibiotic therapy
References (8)
- Sensitive and Specific Serodiagnosis of Lyme Disease by Enzyme-Linked Immunosorbent Assay with a Peptide Based on an Immunodominant Conserved Region ofBorrelia burgdorferiVlsEJournal of Clinical Microbiology · 1999
- Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferiInfection and Immunity · 1993
- Ineffectiveness of Tigecycline against Persistent Borrelia burgdorferiAntimicrobial Agents and Chemotherapy · 2010
- Counterpoint: long-term antibiotic therapy improves persistent symptoms associated with Lyme diseaseClinical Infectious Diseases · 2007
- Point: antibiotic therapy is not the answer for patients with persisting symptoms attributable to Lyme diseaseClinical Infectious Diseases · 2007
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