Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection
Coyle PK, Schutzer SE, Deng Z +4 more2008PLoS ONEJournal Article
CardiovascularImmune/InnateMusculoskeletalNeurological
Lyme & Co-Infections
Abstract
The persistence of symptoms in Lyme disease patients following antibiotic therapy, and their causes, continue to be a matter of intense controversy. The studies presented here explore antibiotic efficacy using nonhuman primates. Rhesus macaques were infected with B. burgdorferi and a portion received aggressive antibiotic therapy 4–6 months later. Multiple
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
B. burgdorferi antigenB. burgdorferi DNAB. burgdorferi RNABorrelia burgdorferi persistenceC6 diagnostic peptide antibodiesSpirochete detection
Symptom Clusters
Chronic Lyme arthritisChronic relapsing infectionNeuroborreliosisPersistent symptoms despite antibiotic therapy
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