Seronegative chronic relapsing neuroborreliosis
Lawrence C, Lipton RB, Lowy FD +1 more1995European NeurologyJournal Article
Neurological
Lyme & Co-Infections
Abstract
We report an unusual patient with evidence of Borrelia burgdorferi infection who experienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had detectable free antibodies to B. burgdorferi in serum or spinal fluid, the CSF was positive on multiple occasions for complexed anti-B. burgdorferi antibodies, B. burgdorferi nucleic acids and free antigen.
Key Biomarkers
Borrelia burgdorferi nucleic acidsComplexed anti-Borrelia burgdorferi antibodiesFree antigen in CSF
Symptom Clusters
Chronic relapsing neuroborreliosisJarisch-Herxheimer-like reaction
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