POMC-derived peptides and their biological action

Abstract

It has long been known that a large number of POMC‐related peptides are found in skin. In this introduction I describe the formation of POMC‐derived peptides in various tissues to indicate that processing is largely tissue‐dependent. I focus on the peptides from the N‐terminal fragment, such as γ‐MSH, ACTH and α‐MSH, and β‐lipopropin as well as β‐endorphin. I touch on the factors that control the synthesis of the various peptides, which are now numerous and varied, and again are tissue specific. The biologic activity of the peptides generated from POMC are described in relation to their possible action in skin. In addition, I describe a new class of peptides induced in skin following injury and which are of great interest.

Part of Actinobacteria research, Endotoxins research, Mold & water-damaged buildings research, Mycotoxins research, CIRS biomarkers research · Curated by Lauren Lowenstein, The Biotoxin Lady

Key Biomarkers

Symptom Clusters