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POMC-derived peptides and their biological action

Solomon S1999Annals of the New York Academy of SciencesReview
10.1111/j.1749-6632.1999.tb08663.xPubMed
CardiovascularDermatologicalEndocrine (ADH/ACTH/MSH)GastrointestinalHypothalamic-PituitaryImmune/InnateMusculoskeletalNeurologicalOcularRespiratory/Sinus
ActinomycetesBacterial EndotoxinsIndoor Mold (Stachybotrys, Aspergillus, etc.)MycotoxinsVolatile Organic Compounds (VOCs)Water-Damaged Buildings (WDB)

Abstract

ABSTRACT:It has long been known that a large number of POMC‐related peptides are found in skin. In this introduction I describe the formation of POMC‐derived peptides in various tissues to indicate that processing is largely tissue‐dependent. I focus on the peptides from the N‐terminal fragment, such as γ‐MSH, ACTH and α‐MSH, and β‐lipopropin as well as β‐endorphin. I touch on the factors that control the synthesis of the various peptides, which are now numerous and varied, and again are tissue specific. The biologic activity of the peptides generated from POMC are described in relation to their possible action in skin. In addition, I describe a new class of peptides induced in skin following injury and which are of great interest.

Key Biomarkers

ACTHAlpha Melanocyte Stimulating Hormone (MSH)alpha-MSHGamma-MSHImmunoglobulin E (IgE)LeptinMatrix Metalloproteinase 9 (MMP9)POMC-derived peptidesVascular Endothelial Growth Factor (VEGF)Visual Contrast Sensitivity (VCS)β-endorphinβ-lipopropin

Symptom Clusters

Appetite swingsChronic painConfusionCoughDifficulty with concentrationExcessive thirstFatigueFrequent urinationHeadacheIce pick painJoint painLight sensitivityMemory lossMood swingsMuscle achesNight sweatsShortness of breathSinus congestionSleep disturbanceTingling in extremities

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    • References (5)

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    • Modulation of ICAM-1 expression by α-MSH in human melanoma cells and melanocytesJournal of Cellular Physiology · 1998
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    • Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptidesNeuroImmunoModulation · 1996
    • Regulation of the immune response by epidermal cytokines and neurohormonesJournal of Dermatological Science · 1996
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