Biological mechanisms of chronic fatigue
Norheim K, Jonsson G, Omdal R2011Lara D. VeekenReview
Endocrine (ADH/ACTH/MSH)Immune/InnateNeurological
Abstract
Chronic fatigue is a common, poorly understood and disabling phenomenon in many diseases. We aim to provide an overview of fatigue in chronic autoimmune and inflammatory disease. Fatigue measurement, prevalence and confounding factors such as depression, sleep disorders and pain are reviewed in the first half of the article. In the second half of the article, we describe explanatory models of fatigue and fatigue signalling, with an emphasis on cytokines and sickness behaviour, oxidative stress, mitochondrial dys- function and the impact of certain genes on fatigue.
Key Biomarkers
Cytokinesmitochondrial dysfunctionOxidative stress
Symptom Clusters
chronic fatiguedepressionpainsickness behavioursleep disorders
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