Pigeon breeder’s lung: association with HLA-DR 3
Abstract
52 symptomatic (SPB) and 64 asymptomatic (APB) pigeon breeders were investigated for the HLA-A, -B, -C, -DR; C2, C3, C4 and Bf systems, and C3, C4 and factor B serum concentrations. HLA-DR3 and Bf S frequencies were significantly higher in the SPB than the APB group. Mean factor B concentrations were lower in the SPB than in the APB group. A positive two-way association between HLA-DR3 and the disease was found. It is concluded that a gene or genes responsible for type III and IV allergic reactions leading to the disease is associated with HLA-DR3. The increase of Bf S allotype and low mean factor B concentrations, however, can be explained by the strong linkage disequilibrium between BfS and HLA-DR3.
Key Biomarkers
Symptom Clusters
Cited By (3)
- Increase of HLA-DR7 in pigeon breeder’s lung in a Mexican populationClinical Immunology and Immunopathology · 1987
- Immunogenetic basis of environmental lung disease: lessons from the berylliosis modelEuropean Respiratory Journal · 1998
- Diagnosis and Treatment of Hypersensitivity Pneumonitis: S2k Guideline of the German Respiratory Society and the German Society for Allergology and Clinical ImmunologyRespiration · 2025
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