From airway inflammation to inflammatory bowel disease: eotaxin-1, a key regulator of intestinal inflammation

Adar T; Shteingart S; Ben Ya'acov A; Bar-Gil Shitrit A; Goldin E

doi:10.1016/j.clim.2014.04.012

From airway inflammation to inflammatory bowel disease: eotaxin-1, a key regulator of intestinal inflammation

Adar T, Shteingart S, Ben Ya'acov A +2 more2014Clinical ImmunologyReview

10.1016/j.clim.2014.04.012 PubMed

GastrointestinalImmune/InnateRespiratory/Sinus

Abstract

Eotaxin-1 (CCL-11) is a potent eosinophil chemoattractant that is considered a major contributor to tissue eosinophilia. Elevated eotaxin-1 levels have been described in various pathologic conditions, ranging from airway inflammation, to Hodgkin lymphoma, obesity and coronary artery disease. The main receptor for eotaxin-1 is CCR3; however, recent evidence indicates that eotaxin-1 may also bind to other receptors expressed by various cell types, suggesting a more widespread regulatory role for eotaxin-1 beyond the recruitment of eosinophils. Eotaxin-1 is also strongly associated with various gastrointestinal (GI) disorders. Although the etiology of inflammatory bowel disease (IBD) is still unknown, eotaxin-1 may play a key role in the development of mucosal inflammation. In this review, we summarize the biological context and effects of eotaxin-1, as well as its potential role as a therapeutic target, with a special focus on gastrointestinal inflammation.

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady

Key Biomarkers

CCR3Eotaxin-1 (CCL-11)

Symptom Clusters

Airway inflammationIntestinal inflammationMucosal inflammationTissue eosinophilia