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Dectin-1: a signalling non-TLR pattern-recognition receptor

Brown GD2006Nature reviews. ImmunologyReview
10.1038/nri1745PubMed
Immune/Innate
Beta-GlucansIndoor Mold (Stachybotrys, Aspergillus, etc.)

Abstract

Dectin-1 is a natural killer (NK)-cell-receptor-like C-type lectin that is thought to be involved in innate immune responses to fungal pathogens. This transmembrane signalling receptor mediates various cellular functions, from fungal binding, uptake and killing, to inducing the production of cytokines and chemokines. These activities could influence the resultant immune response and can, in certain circumstances, lead to autoimmunity and disease. As I discuss here, understanding the molecular mechanisms behind these functions has revealed new concepts, including collaborative signalling with the Toll-like receptors (TLRs) and the use of spleen tyrosine kinase (SYK), that have implications for the role of other non-TLR pattern-recognition receptors in immunity.

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    • References (1)

    • Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profileJournal of Leukocyte Biology · 2004